Chronic liver disease, thrombocytopenia and procedural bleeding risk; are novel thrombopoietin mimetics the solution?
Chronic liver disease (CLD) alters normal hemostatic and thrombotic systems via multiple mechanisms Golf Ball including reduced platelet function and number, leading to challenging peri-operative planning.Hepatic thrombopoietin (TPO) synthesis is reduced in CLD, leading to several recent randomized, placebo-controlled trials examining the utility o